ea0031oc2.6 | Steroids and thyroid | SFEBES2013
Bentley Liz
, Esapa Christopher T
, Nesbit M Andrew
, Head Rosie A
, Evans Holly
, Lath Darren
, Hough Tertius A
, Podrini Christine
, Fraser William D
, Croucher Peter I
, Brown Matthew A
, Brown Steve D M
, Cox Roger D
, Thakker Rajesh V
Cushings syndrome, which is characterised by excessive circulating glucocorticoid (GC) concentrations, may be due to ACTH-dependent or -independent causes that include anterior pituitary and adrenal cortical tumours, respectively. In the course of our phenotype-driven screens of mouse mutants induced by the chemical mutagen N-ethyl-N-nitrosourea (ENU), we observed a mutant mouse with obesity, hyperglycaemia and low bone mineral density, features that ar...